Randomized double-blind placebo-controlled (RDBPC) studies are often hailed as the “gold standard” in epidemiologic research. This designation stems from their rigorous design aimed at minimizing cognitive biases that […]
Technology
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Root Cause Analysis (RCA)
Root cause analysis is a structured team process that assists in identifying underlying factors or causes of an adverse event or near-miss. Understanding the contributing factors or causes […]
Industry
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Process Validation
In the biotech industry, process validation is a crucial step in ensuring the quality, consistency, and reliability of manufacturing processes, particularly for pharmaceuticals, biologics, and other biological products.Process […]
Personal
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Personal Update
Just four days after my previous post and a month following my post on 2023’s biotech layoffs, I found myself affected by them, an outcome I hadn’t foreseen […]
Technology
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Doggybone Plasmid DNA
E. Coli fermentation is the conventional way of producing pDNA and is widely adopted in the biotech industry. However the long lead time and high cost associated with […]
Technology
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Plasmid DNA
A plasmid is a small, double-stranded, circular DNA molecule found in bacteria and some other microscopic organisms. Unlike genomic DNA, which is chromosomal DNA, plasmid DNA is extrachromosomal […]
Technology
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Why E. coli Doesn’t Like to Transcribe Poly(A) Tail?
Eukaryotic mRNA consists of several parts: the 5′ Cap, 5′ UTR, coding sequence, 3′ UTR, and 3′ poly(A) tail. The poly(A) tail plays a critical role in stabilizing […]
Chemistry
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Sugars and Lipids – Chemical Structure
Sugars and lipids are two distinct classes of biomolecules found in living organisms, each with its own unique chemical composition, structure, and functions. Today, we will focus solely […]
Technology
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GalNAc
GalNAc, or N-acetylgalactosamine, is a sugar molecule with its chemical structure shown in Figure 1. It can recognize and bind to a cell surface protein, the asialoglycoprotein receptor […]
News / Technology
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Base Editing
On November 13, 2023, Verve Therapeutics shared positive early Phase I results from the first in vivo base editing human trial, demonstrating “Dose-Dependent Reductions in LDL-C and Blood […]